PUBLICATIONS
Thomas N. Thompson, Ph.D.
Dr. Thompson has authored or presented 31 manuscripts reviews or book chapters, 22 invited platform presentations, and 46 abstracts presented at national meetings.
Selected Thompson publications
Effect of MMX Mesalamine Coadministration on the Pharmacokinetics of Amoxicillin, Ciprofloxacin XR, Metronidazole, and Sulfamethoxazole: Results From 4 Randomized Clinical Trials Pierce D, Corcoran M, Martin P, Karen Barrett K, Inglis S, Preston P, Thompson TN and Willsie SK. Drug Des Devel There 2014 May 14; 8:529-43.
Pharmacokinetics and tissue and tumor exposure of CP-31398, a p53-stabilizing agent, in rats. Kapetanovic IM, Muzzio M, McCormick DL, Thompson TN, Johnson WD, Horn TL, Mohammed A, Rao CV, Kopelovich L. Cancer Chemother Pharmacol. 2012 May; 69(5):1301-6
Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats. Izet M. Kapetanovic, Miguel Muzzio, Zhihua Huang, Thomas N. Thompson and David L. McCormick. Cancer Chemother Pharmacol. 2011 Sep; 68 (3):593-601
The clinical significance of drug transporters in drug disposition and drug interactions, Thomas N. Thompson. In: Pharmacokinetics in Drug Development, Vol 3. Peter Bonate and Danny Howard, editors. Springer Verlag, 2010, chapter 13, pp 285-313
Drug Metabolism In-vitro and In-vivo Results: How do These Data Support Drug Discovery? Thomas N. Thompson, in “Using Mass Spectrometry for Drug Metabolism” (Walter Korfmacher, ed.) CRC Press, Boca Raton, FL, 2005
A Graphical Method for Estimating Oral Bioavailability of Drugs in Humans and Other Species from Their Caco-2 Permeability and In vitro Liver Enzyme Metabolic Stability Rates. Arun K. Mandagere, Thomas N. Thompson, and Kin-Kai Hwang. J Med Chem 45(2) 304-311 (2002)
Optimization of Metabolic Stability as a Goal of Modern Drug Design Thomas N. Thompson Medicinal Research Reviews, 21(5) 412-449 (2001).
Evaluation of the BBMEC model for screening the CNS permeability of drugs Kenneth W. Otis, Michael L. Avery, Suzanne M. Broward-Partin, Dannette K. Hansen, Herbert W., Jr. Behlow, Dennis O. Scott, Thomas N. Thompson Journal of Pharmacological and Toxicological Methods:45(1):71-77 (2001)
Early ADME in support of drug discovery: The role of metabolic stability studies Thomas N. Thompson Current Drug Metabolism 1: 215-241 2000
A strategy for use of in vitro metabolism studies to evaluate potential drug-drug interactions : M100907 as a case study in “Predicting Drug Metabolism” Thomas N. Thompson (Natalie S. Rudolph, Ph.D. and Martha H. Tulloch, eds) AdvanceTech Monitor, Woburn, MA, pp 96-106, 2000
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GREG KOCHAK, PH.D.
Dr. Kochak has authored 9 invited presentations, 39 manuscripts, reviews or book chapters and 33 platform presentations or abstracts at national meetings.
Selected Kochak publications
Sarkar, A.B. and Kochak, G.M., “Hydrophilic carbohydrate nanocapsules as a sustained delivery depot of small and macromolecular drugs: Preformulation and mass transfer”, Int. J. Pharm. Sci. Rev. Res. 13:19-27 (2012).
Sarkar, A.B., Kestur, U. and Kochak, G.M., “Interfacially Assembled Carbohydrate Nanocapsules: A Hydrophilic Macromolecule Delivery Platform”, J. Biomed. Nanotechnology 5: 456-463 (2009).
Sarkar, A.B. and Kochak, G.M., “HPLC Analysis of Aliphatic and Aromatic Dicarboxylic Acid Cross-Linkers Hydrolyzed from Carbohydrate Polyesters for Estimation of the Molar Degree of Substitiution”, Carbohydrate Polymers, 59: 305 (2005).
Kochak, G.M., and Mangat, S., “Transepithelial Ultrafiltration and Fractal Power Diffusion of D-Glucose in the Perfused Rat Intestine”, Biochim. Biophys. Acta, Biomembranes 1567:87 (2002).
Kochak, G.M., Page, J.G., Buchanan, R.A., Peters, R., and Padgett, C.S., "Steady State Pharmacokinetics of Zonisamide, An Antiepileptic for Refractory Complex Partial Seizures", J. Clin. Pharmacol., 38:166 (1998).
Morgan, J.M., Piraino, A.J., Saris, S.D., Graham, C.S., Hirschhorn, W.L., Kochak, G.M., and Choi, R.L., "Inhibition of Angiotensin-Converting Enzyme with Libenzapril in Normotensive Males ", J. Clin. Pharmacol., 34:1177 (1994).
Choi, R.L., Sun, J.X., and Kochak, G.M., " Effect of Food on the Relative Bioavailability of Fadrozole Hydrochloride", Biopharm. Drug Dispos., 14: 779 (1993).
Kochak, G.M., Pai, S., Iannucci, R., Honc, F., Kachmar, D., Perrino, P., and Egger, H., "Prinomide Tromethamine Pharmacokinetics: Mutually Dependent Saturable and Competitive Protein Binding Between Prinomide and its Own Metabolite", Pharm. Res., 10: 49 (1993).
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DON REYNOLDS, PH.D.
Dr. Reynolds has authored 18 invited platform presentations, 21 manuscripts, reviews or book chapters and 18 abstracts presented at national meetings
Selected Reynolds publications
LC-MS/MS Matrix Effects - Mechanisms, Sources, Evaluation and Strategies to Minimize, Donald L. Reynolds, Invited Speaker, Lotus Labs Pvt. Ltd., Bangalore, India, September 2007.
HPLC Column Switching – Introduction and Selected Applications, Donald L. Reynolds, Invited Speaker, Lotus Labs Pvt. Ltd., Bangalore, India, July 2007.
COMPARISON OF BIOLOGICAL AND CHEMICAL ASSAYS FOR THE QUANTITATION OF RIFAPENTINE IN HUMAN PLASMA, Michael T. Kenny, Donald L. Reynolds, Marcia A. Brackman and Jacqueline K. Dulworth, Diagn. Microbiol. Infect. Dis., 27, 1997, pp. 107-111.
AN INVESTIGATION OF THE DOSE PROPORTIONALITY OF DEFLAZACORT PHARMACOKINETICS, Niranjan Rao, Vijay O. Bhargava, Donald L. Reynolds, Mark G. Eller and Scott J. Weir, Biopharm. Drug Disp., 17, 1996, pp. 753-760.
Pharmacokinetics and Pharmacodynamics of the Monoamine Oxidase B Inhibitor MOFEGILINE Assessed During a Phase I Dose Tolerance Trial, Maxine Stoltz, Donald Reynolds, Linda Elkins, Daniel Salazar and Scott Weir, Clin. Pharmacol. Ther., 58(3), 1995, pp. 342-353.
Quantitative Determination of 21-Hydroxy-deflazacort in Human Plasma Using Gradient Semi-Microbore Liquid Chromatography, Donald L. Reynolds, Steve D. Burmaster and Larry S. Eichmeier, Biomed. Chromatogr., 8, 1994, pp. 230-235.